CARDIAC TROPONIN T LEVELS IN END-STAGE RENAL DISEASE PATIENTS UNDERGOING HEMODIALYSIS AT JARAMOGI OGINGA ODINGA TEACHING HOSPITAL, WESTERN KENYA: CROSS-SECIONAL STUDY DESIGN

Abstract

Background: End-Stage Kidney Disease (ESKD) is a critical global health issue, particularly in low-resource settings like Kenya, where limited access to specialized care and dialysis exacerbates its rising prevalence and underreporting. Methods: This study aimed at determining the cardiac troponin T levels in ESKD patients undergoing hemodialysis at Jaramogi Oginga Odinga Teaching Hospital (JOOTRH), Kisumu County, Kenya. This study employed a cross-sectional descriptive research design, examining 71 patients with ESKD. Besides cardiac troponin T, the whole blood (3-5 mL) was analyzed for kidney biochemical parameters. Descriptive statistics and Chi-square test was used to examine associations between dependent and independent variables using SPSS software version 25.
Results: The study included 71 (n=100) participants, 50.7% (n=36) were female and 49.3% (n=35) were male. The study observed that 98.6% (n=70) had elevated levels of cardiac Troponin T. Gender was significantly associated with phosphorus levels, with an odds ratio of 0.33 (95% CI: 0.11–0.98) and a p-value of 0.042. While no kidney biochemical parameters, except chloride, were significantly linked to cardiac Troponin T levels.
Conclusion: This study highlights the interplay between dialysis practices, biochemical disturbance, and cardiovascular risk in ESKD.

Recommendation: Management of ESKD to adopt a personalized approach that incorporates, the demographic factors, biochemical profiles to optimize renal and cardiovascular outcomes.